1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries

Lori I. Robins; Mark J. Kurth

doi:10.1021/ol062466d

1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries

Lori I. Robins, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

(Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.

Original language	English (US)
Pages (from-to)	171-173
Number of pages	3
Journal	Organic Letters
Volume	9
Issue number	2
DOIs	https://doi.org/10.1021/ol062466d
State	Published - Jan 18 2007

ASJC Scopus subject areas

Molecular Medicine

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abstract = "(Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.",

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AU - Kurth, Mark J.

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AB - (Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.

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