Abstract
(Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-173 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 18 2007 |
Fingerprint
ASJC Scopus subject areas
- Molecular Medicine
Cite this
1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries. / Robins, Lori I.; Kurth, Mark J.
In: Organic Letters, Vol. 9, No. 2, 18.01.2007, p. 171-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries
AU - Robins, Lori I.
AU - Kurth, Mark J.
PY - 2007/1/18
Y1 - 2007/1/18
N2 - (Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.
AB - (Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.
UR - http://www.scopus.com/inward/record.url?scp=33846561586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846561586&partnerID=8YFLogxK
U2 - 10.1021/ol062466d
DO - 10.1021/ol062466d
M3 - Article
C2 - 17217257
AN - SCOPUS:33846561586
VL - 9
SP - 171
EP - 173
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 2
ER -