1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries

Lori I. Robins, Mark J. Kurth

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

(Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalOrganic Letters
Volume9
Issue number2
DOIs
StatePublished - Jan 18 2007

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Triazines
beads
resins
Libraries
marking
isotopic labeling
Ionization potential
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
decoding
ionization potentials
Labeling
Decoding
coding
reactivity
Resins
Experiments
1-oxa-2,8-diazaspiro(4.5)dec-2-ene-7-carboxamide
Tentagel resin

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries. / Robins, Lori I.; Kurth, Mark J.

In: Organic Letters, Vol. 9, No. 2, 18.01.2007, p. 171-173.

Research output: Contribution to journalArticle

Robins, Lori I. ; Kurth, Mark J. / 1,3,5-Triazine-based mass spectral tagging of one-bead one-compound libraries. In: Organic Letters. 2007 ; Vol. 9, No. 2. pp. 171-173.
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