Abstract
(Chemical Equation Presented) A triazine-based mass encoding strategy that accommodates cleavable linker, isotopic labeling, and diversity receptor moieties is reported. The resulting triazine-based tags, which are coupled to bifunctionalized TentaGel resin in a one-pot transformation, enable the construction of a 1-oxa-2,8-diazaspiro[4.5]dec-2-ene-7-carboxamide library and facilitate decoding by equalizing the ionization potential of the liberated tags in single bead MALDI-TOF experiments as well as balancing the reactivity of the starting tags in the resin coupling step.
Original language | English (US) |
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Pages (from-to) | 171-173 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Jan 18 2007 |
ASJC Scopus subject areas
- Molecular Medicine