125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young

C. Naidoo, I. Jialal, R. Haneef, S. M. Joubert

Research output: Contribution to journalArticle

Abstract

125 I-insulin binding to circulating monocytes was found to be decreased in Indian patients with non-insulin-dependent diabetes in the young, when compared to controls. To determine whether this was due to an inherent defect in the insulin receptor, fibroblasts from diabetics and controls were grown in an environment free from the diabetic milieu. Under these conditions 125 I-insulin binding to fibroblasts in patients with non-insulin-dependent diabetes in the young was similar to that obtained in controls. (1.5 ± 0.4% and 1.3 ± 0.3% per 106 cells, p > 0.5). It thus appears that the receptor defect manifest on circulating monocytes is unlikely to be a primary defect.

Original languageEnglish (US)
Pages (from-to)222-224
Number of pages3
JournalDiabete et Metabolisme
Volume13
Issue number3
StatePublished - 1987
Externally publishedYes

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Monocytes
Fibroblasts
Insulin
Defect in Insulin Receptor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Naidoo, C., Jialal, I., Haneef, R., & Joubert, S. M. (1987). 125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young. Diabete et Metabolisme, 13(3), 222-224.

125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young. / Naidoo, C.; Jialal, I.; Haneef, R.; Joubert, S. M.

In: Diabete et Metabolisme, Vol. 13, No. 3, 1987, p. 222-224.

Research output: Contribution to journalArticle

Naidoo, C, Jialal, I, Haneef, R & Joubert, SM 1987, '125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young', Diabete et Metabolisme, vol. 13, no. 3, pp. 222-224.
Naidoo, C. ; Jialal, I. ; Haneef, R. ; Joubert, S. M. / 125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young. In: Diabete et Metabolisme. 1987 ; Vol. 13, No. 3. pp. 222-224.
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