Abstract
125 I-insulin binding to circulating monocytes was found to be decreased in Indian patients with non-insulin-dependent diabetes in the young, when compared to controls. To determine whether this was due to an inherent defect in the insulin receptor, fibroblasts from diabetics and controls were grown in an environment free from the diabetic milieu. Under these conditions 125 I-insulin binding to fibroblasts in patients with non-insulin-dependent diabetes in the young was similar to that obtained in controls. (1.5 ± 0.4% and 1.3 ± 0.3% per 106 cells, p > 0.5). It thus appears that the receptor defect manifest on circulating monocytes is unlikely to be a primary defect.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 222-224 |
| Number of pages | 3 |
| Journal | Diabete et Metabolisme |
| Volume | 13 |
| Issue number | 3 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young. / Naidoo, C.; Jialal, I.; Haneef, R.; Joubert, S. M.
In: Diabete et Metabolisme, Vol. 13, No. 3, 1987, p. 222-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 125 I-insulin binding to cultured fibroblasts in non-insulin-dependent diabetes in the young
AU - Naidoo, C.
AU - Jialal, I.
AU - Haneef, R.
AU - Joubert, S. M.
PY - 1987
Y1 - 1987
N2 - 125 I-insulin binding to circulating monocytes was found to be decreased in Indian patients with non-insulin-dependent diabetes in the young, when compared to controls. To determine whether this was due to an inherent defect in the insulin receptor, fibroblasts from diabetics and controls were grown in an environment free from the diabetic milieu. Under these conditions 125 I-insulin binding to fibroblasts in patients with non-insulin-dependent diabetes in the young was similar to that obtained in controls. (1.5 ± 0.4% and 1.3 ± 0.3% per 106 cells, p > 0.5). It thus appears that the receptor defect manifest on circulating monocytes is unlikely to be a primary defect.
AB - 125 I-insulin binding to circulating monocytes was found to be decreased in Indian patients with non-insulin-dependent diabetes in the young, when compared to controls. To determine whether this was due to an inherent defect in the insulin receptor, fibroblasts from diabetics and controls were grown in an environment free from the diabetic milieu. Under these conditions 125 I-insulin binding to fibroblasts in patients with non-insulin-dependent diabetes in the young was similar to that obtained in controls. (1.5 ± 0.4% and 1.3 ± 0.3% per 106 cells, p > 0.5). It thus appears that the receptor defect manifest on circulating monocytes is unlikely to be a primary defect.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023278408&partnerID=8YFLogxK
M3 - Article
C2 - 3609424
AN - SCOPUS:0023278408
VL - 13
SP - 222
EP - 224
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
SN - 1262-3636
IS - 3
ER -