1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca2+ channel

Makoto N. Masuno, Alexander C. Hoepker, Isaac N Pessah, Tadeusz F. Molinski

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and -2 were antagonists of the RyR1-FKBP12 Ca 2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2 μM).

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalMarine Drugs
Volume2
Issue number4
DOIs
StatePublished - 2004

Keywords

  • Bromotyrosine
  • Calcium channel
  • Porifera
  • Ryanodine receptor

ASJC Scopus subject areas

  • Drug Discovery

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