1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca2+ channel

Makoto N. Masuno, Alexander C. Hoepker, Isaac N Pessah, Tadeusz F. Molinski

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and -2 were antagonists of the RyR1-FKBP12 Ca 2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2 μM).

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalMarine Drugs
Volume2
Issue number4
DOIs
StatePublished - 2004

Fingerprint

Tacrolimus Binding Protein 1A
Guam
Ryanodine Receptor Calcium Release Channel
Porifera
Sulfates
phosphinothricin
bastadin 5

Keywords

  • Bromotyrosine
  • Calcium channel
  • Porifera
  • Ryanodine receptor

ASJC Scopus subject areas

  • Drug Discovery

Cite this

1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca2+ channel. / Masuno, Makoto N.; Hoepker, Alexander C.; Pessah, Isaac N; Molinski, Tadeusz F.

In: Marine Drugs, Vol. 2, No. 4, 2004, p. 176-184.

Research output: Contribution to journalArticle

Masuno, Makoto N. ; Hoepker, Alexander C. ; Pessah, Isaac N ; Molinski, Tadeusz F. / 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca2+ channel. In: Marine Drugs. 2004 ; Vol. 2, No. 4. pp. 176-184.
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