ω-Conotoxin-MVIID blocks an ω-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells

Toshihide Tabata, Baldomero M. Olivera, Andrew Ishida

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Deduction of Ca2+ current amplitude by the Conus peptide ω-conotoxin-MVIID (ω-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of ω-CTx-MVIID, ω-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and ω-Aga-IIIA, indicate that ω-CTx-MVIID may target Ca2+ channels differing from those termed T, L, N, P, Q and R.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalNeuropharmacology
Volume35
Issue number5
DOIs
StatePublished - May 1996

Keywords

  • ω-conotoxin-GVIA
  • ω-conotoxin-MVIID
  • BAY-K-8644
  • Goldfish
  • Retinal ganglion cell

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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