ω-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

Weicang Wang, Julia Zhu, Fei Lyu, Dipak Panigrahy, Katherine W. Ferrara, Bruce Hammock, Guodong Zhang

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of ω-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which ω-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The ω-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived ω-3-series lipid metabolites on angiogenesis, inflammation and cancer.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume113-115
DOIs
StatePublished - Jul 11 2014

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Keywords

  • Cyclooxygenase
  • Cytochrome P450
  • Lipoxygenase
  • ω-3 polyunsaturated fatty acids

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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