γ-linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters

Vincent A. Ziboh, Monica Yun, Dallas M. Hyde, Shri N. Giri

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Although bleomycin (BLM), an antineoplastic drug, is used in the treatment of a variety of tumors, the mechanism(s) that contribute to its induced lung injury and fibrosis are not fully elucidated. Since alterations in the levels of certain fatty acid metabolites have been associated with BLM-induced lung injury, we tested the effects of dietary γ-linolenic acid (GLA)-containing evening primrose oil on BLM-induced morphological alterations in the hamster lung, the marked elevation of tissue hydroxyproline (a marker for collagen synthesis), and elevated generation of arachidonic acid metabolites (marker of inflammatory mediators). Our data revealed that after 14 d of dietary GLA-containing oil (i) BLM-induced elevation of lung hydroxyproline was suppressed (P < 0.05), (ii) the marked BLM-induced elevation of lung leukotriene B4 (LTB4) (a marker of polymorphonuclear generation of proinflammatory LTB4) was significantly suppressed (P< 0.05). The decrease in LTB4 was accompanied by marked elevations (P < 0.05) of lung prostaglandin E1 (PGE1) and 15- hydroxyeicosatrienoic acid (15-HETrE), both with known antiinflammatory properties. Taken together, data from these studies suggest that dietary GLA- containing oil contributes to tissue elevation of PGE1 and 15-HETrE, which in vivo may attenuate lung inflammation and fibrosis.

Original languageEnglish (US)
Pages (from-to)759-767
Number of pages9
JournalLipids
Volume32
Issue number7
DOIs
StatePublished - Jul 1997

Fingerprint

alpha-Linolenic Acid
Bleomycin
Nutrition
linolenic acid
fibrosis
hamsters
Cricetinae
Fibrosis
lungs
Leukotriene B4
Diet
Lung
leukotrienes
diet
Alprostadil
Hydroxyproline
Lung Injury
Metabolites
Oils
hydroxyproline

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

γ-linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. / Ziboh, Vincent A.; Yun, Monica; Hyde, Dallas M.; Giri, Shri N.

In: Lipids, Vol. 32, No. 7, 07.1997, p. 759-767.

Research output: Contribution to journalArticle

Ziboh, Vincent A. ; Yun, Monica ; Hyde, Dallas M. ; Giri, Shri N. / γ-linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. In: Lipids. 1997 ; Vol. 32, No. 7. pp. 759-767.
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