γ-H2AX illuminates meiosis

Neil Hunter, G. Valentin Börner, Michael Lichten, Nancy Kleckner

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The temporal and functional relationships between the DNA events of meiotic recombination and the synaptonemal complex (SC), a meiosis-specific structure formed between homolog axes, are subjects of intense discussion and investigation. A new study provides evidence that initiation of recombination (through programmed double-strand breaks (DSBs)) precedes initiation of SC formation, and further suggests that progression of recombination is required for formation of SC on a region-by-region basis. These conclusions derive from immunocytological analysis of a phosphorylated histone variant, γ-H2AX, previously found to be characteristic of DSB repair in mitotic cells, and shown here to be recruited for specialized use during meiosis.

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalNature Genetics
Volume27
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Hunter, N., Valentin Börner, G., Lichten, M., & Kleckner, N. (2001). γ-H2AX illuminates meiosis. Nature Genetics, 27(3), 236-238. https://doi.org/10.1038/85781