γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity

Cuong Thach Nguyen, Emanual Maverakis, Matthias Eberl, Iannis E. Adamopoulos

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. γδ T cells are non-conventional lymphocytes, which express T cell receptor (TCR) γδ chains on their surface and straddle between innate and adaptive immunity. Recent advances in of γδ T cell biology have allowed us to expand our understanding of γδ T cell in the dysregulation of immune responses and the development of autoimmune diseases. In this review, we summarize current knowledge on γδ T cells and their roles in skin and joint inflammation as commonly observed in rheumatic diseases.

Original languageEnglish (US)
Pages (from-to)595-605
Number of pages11
JournalSeminars in immunopathology
Volume41
Issue number5
DOIs
StatePublished - Sep 1 2019

Keywords

  • Autoimmune diseases
  • Bone remodeling
  • Psoriatic arthritis
  • Skin and joint inflammation
  • T cell receptor (TCR)
  • γδ T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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