Β2 adrenergic receptor, protein kinase a (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in alzheimer disease models

Dayong Wang, Qin Fu, Yuan Zhou, Bing Xu, Qian Shi, Benedict Igwe, Lucas Matt, Johannes W Hell, Elena V. Wisely, Salvatore Oddo, Yang Kevin Xiang

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Accumulating evidence indicates that βreceptors (βAR) may be involved in Alzheimer disease (AD) pathology and that amyloid βpeptide (Aβ) may interact with β2AR independently of presynaptic activities. Results: β2AR, PKA, and JNK mediate Aβ-induced phosphorylation of tau in vivo and in vitro. Conclusion: An Aβ-β2AR signaling is involved in tau pathology in AD. Significance: This work indicates a potential mechanism for altering AD pathology by blocking β2ARs.

Original languageEnglish (US)
Pages (from-to)10298-10307
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number15
DOIs
StatePublished - Apr 12 2013

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JNK Mitogen-Activated Protein Kinases
Pathology
Adrenergic Receptors
Protein Kinases
Alzheimer Disease
Phosphorylation
Amyloid

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Β2 adrenergic receptor, protein kinase a (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in alzheimer disease models. / Wang, Dayong; Fu, Qin; Zhou, Yuan; Xu, Bing; Shi, Qian; Igwe, Benedict; Matt, Lucas; Hell, Johannes W; Wisely, Elena V.; Oddo, Salvatore; Xiang, Yang Kevin.

In: Journal of Biological Chemistry, Vol. 288, No. 15, 12.04.2013, p. 10298-10307.

Research output: Contribution to journalArticle

Wang, Dayong ; Fu, Qin ; Zhou, Yuan ; Xu, Bing ; Shi, Qian ; Igwe, Benedict ; Matt, Lucas ; Hell, Johannes W ; Wisely, Elena V. ; Oddo, Salvatore ; Xiang, Yang Kevin. / Β2 adrenergic receptor, protein kinase a (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in alzheimer disease models. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 15. pp. 10298-10307.
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AU - Shi, Qian

AU - Igwe, Benedict

AU - Matt, Lucas

AU - Hell, Johannes W

AU - Wisely, Elena V.

AU - Oddo, Salvatore

AU - Xiang, Yang Kevin

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