β2 adrenergic receptor complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for pharmacological targeting of protein interactions

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Formation of signaling complexes is crucial for the orchestration of fast, efficient, and specific signal transduction. Pharmacological disruption of defined signaling complexes has the potential for specific intervention in selected regulatory pathways without affecting organism-wide disruption of parallel pathways. Signaling by epinephrine and norepinephrine through α and β adrenergic receptors acts on many signaling pathways in many cell types. Here, we initially provide an overview of the signaling complexes formed between the paradigmatic β2 adrenergic receptor and two of its most important targets, the L-type Ca2+ channel CaV1.2 and the AMPA-type glutamate receptor. Importantly, both complexes contain the trimeric Gs protein, adenylyl cyclase, and the cAMP-dependent protein kinase, PKA. We then discuss the functional implications of the formation of these complexes, how those complexes can be specifically disrupted, and how such disruption could be utilized in the pharmacological treatment of disease.

Original languageEnglish (US)
Pages (from-to)155-174
Number of pages20
JournalAnnual Review of Pharmacology and Toxicology
Volume60
DOIs
StatePublished - Jan 6 2020

Keywords

  • adenylyl cyclase
  • AKAP
  • cAMP
  • G
  • norepinephrine
  • PSD-95

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'β<sub>2</sub> adrenergic receptor complexes with the L-Type Ca<sup>2+</sup> Channel Ca<sub>V</sub>1.2 and AMPA-Type Glutamate Receptors: Paradigms for pharmacological targeting of protein interactions'. Together they form a unique fingerprint.

  • Cite this