Abstract
Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5617-5622 |
| Number of pages | 6 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 30 |
| State | Published - Jul 22 2000 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Alonso, C., Nantz, M. H., & Kurth, M. J. (2000). β-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry. Tetrahedron Letters, 41(30), 5617-5622.