Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Jul 22 2000|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery