β-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry

Concepción Alonso, Michael H. Nantz, Mark J. Kurth

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)5617-5622
Number of pages6
JournalTetrahedron Letters
Volume41
Issue number30
StatePublished - Jul 22 2000

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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    Alonso, C., Nantz, M. H., & Kurth, M. J. (2000). β-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry. Tetrahedron Letters, 41(30), 5617-5622.