β-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry

Concepción Alonso; Michael H. Nantz; Mark J. Kurth

β-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry

Concepción Alonso, Michael H. Nantz, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	5617-5622
Number of pages	6
Journal	Tetrahedron Letters
Volume	41
Issue number	30
State	Published - Jul 22 2000

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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abstract = "Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.",

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T1 - β-Dimethylphenylsilylethyl esters

T2 - A linker for solid-phase chemistry

AU - Alonso, Concepción

AU - Nantz, Michael H.

AU - Kurth, Mark J.

PY - 2000/7/22

Y1 - 2000/7/22

N2 - Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.

AB - Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 30

ER -

β-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry

Abstract

ASJC Scopus subject areas

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