Abstract
Preparation of a β-dimethylphenylsilylethyl (BMPSE) ester linker from 2% divinylbenzene-styrene copolymer by lithiation, chlorodimethylvinylsilane silylation, hydroboration/oxidation (giving 9), and O-acylation is reported. The resulting polymer-bound BMPSE esters were employed in a reaction sequence consisting of RCHO→RCH=NOH→isoxazoline/isoxazole (giving 12). (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 5617-5622 |
Number of pages | 6 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 30 |
State | Published - Jul 22 2000 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery