β-Carboline-induced anxiety states

P. Skolnick, Jacqueline Crawley, J. R. Glowa, S. M. Paul

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Several C-3-substituted β-carbolines (e.g., the ethyl ester of β-carboline-3-carboxylic acid) have high affinities for benzodiazepine receptors and can antagonize the principal pharmacologic actions of the benzodiazepines. The observation that some of these compounds also possess 'intrinsic' actions, best described as pharmacologically opposite to the benzodiazepines, has provided a chemically induced model of extreme stress or anxiety. The actions of such compounds in currently used animal models of anxiety are reviewed, as well as the effects of these compounds in primates, including man.

Original languageEnglish (US)
Pages (from-to)52-60
Number of pages9
JournalPsychopathology
Volume17
Issue numberSUPPL. 3
StatePublished - 1984
Externally publishedYes

Fingerprint

Carbolines
Benzodiazepines
Anxiety
Pharmacologic Actions
GABA-A Receptors
Primates
Esters
Animal Models
carboline-3-carboxylic acid

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Skolnick, P., Crawley, J., Glowa, J. R., & Paul, S. M. (1984). β-Carboline-induced anxiety states. Psychopathology, 17(SUPPL. 3), 52-60.

β-Carboline-induced anxiety states. / Skolnick, P.; Crawley, Jacqueline; Glowa, J. R.; Paul, S. M.

In: Psychopathology, Vol. 17, No. SUPPL. 3, 1984, p. 52-60.

Research output: Contribution to journalArticle

Skolnick, P, Crawley, J, Glowa, JR & Paul, SM 1984, 'β-Carboline-induced anxiety states', Psychopathology, vol. 17, no. SUPPL. 3, pp. 52-60.
Skolnick P, Crawley J, Glowa JR, Paul SM. β-Carboline-induced anxiety states. Psychopathology. 1984;17(SUPPL. 3):52-60.
Skolnick, P. ; Crawley, Jacqueline ; Glowa, J. R. ; Paul, S. M. / β-Carboline-induced anxiety states. In: Psychopathology. 1984 ; Vol. 17, No. SUPPL. 3. pp. 52-60.
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