Abstract
Adrenergic receptors and their downstream effector molecules are expressed in all cell types in the skin, and it is only recently that functionality of the catecholamine agonist activated signaling in the cutaneous repair process has been revealed. In addition to responding to systemic elevations in catecholamines (as in stress situations) or to pharmacologically administered adrenergic agonists, epidermal keratinocytes themselves can synthesize catecholamine ligands. They also respond to these systemic or self-generated agonists via receptor mediated signaling, resulting in altered migration, and changes in wound re-epithelialization. Endothelial cells, inflammatory cells, dermal fibroblasts, and mesenchymal stem cells, all cells that contribute to the wound repair process, express multiple subtypes of adrenergic receptors and exhibit responses that can be either contribute or impair healing-and occasionally, depending on the species and assay conditions, results can be conflicting. There is still much to be uncovered regarding how this self-contained autocrine and paracrine signaling system contributes to cutaneous wound repair.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 158-164 |
| Number of pages | 7 |
| Journal | Pharmacological Research |
| Volume | 58 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2008 |
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Keywords
- β-Adrenergic receptor
- Angiogenesis
- Dermal fibroblast
- Inflammation
- Keratinocyte migration
- Re-epithelialization
- Wound contraction
- Wound healing
ASJC Scopus subject areas
- Pharmacology
Cite this
β-Adrenergic receptor modulation of wound repair. / Pullar, Christine E.; Manabat-Hidalgo, Catherine G.; Bolaji, Ranti S.; Isseroff, Roslyn Rivkah.
In: Pharmacological Research, Vol. 58, No. 2, 08.2008, p. 158-164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - β-Adrenergic receptor modulation of wound repair
AU - Pullar, Christine E.
AU - Manabat-Hidalgo, Catherine G.
AU - Bolaji, Ranti S.
AU - Isseroff, Roslyn Rivkah
PY - 2008/8
Y1 - 2008/8
N2 - Adrenergic receptors and their downstream effector molecules are expressed in all cell types in the skin, and it is only recently that functionality of the catecholamine agonist activated signaling in the cutaneous repair process has been revealed. In addition to responding to systemic elevations in catecholamines (as in stress situations) or to pharmacologically administered adrenergic agonists, epidermal keratinocytes themselves can synthesize catecholamine ligands. They also respond to these systemic or self-generated agonists via receptor mediated signaling, resulting in altered migration, and changes in wound re-epithelialization. Endothelial cells, inflammatory cells, dermal fibroblasts, and mesenchymal stem cells, all cells that contribute to the wound repair process, express multiple subtypes of adrenergic receptors and exhibit responses that can be either contribute or impair healing-and occasionally, depending on the species and assay conditions, results can be conflicting. There is still much to be uncovered regarding how this self-contained autocrine and paracrine signaling system contributes to cutaneous wound repair.
AB - Adrenergic receptors and their downstream effector molecules are expressed in all cell types in the skin, and it is only recently that functionality of the catecholamine agonist activated signaling in the cutaneous repair process has been revealed. In addition to responding to systemic elevations in catecholamines (as in stress situations) or to pharmacologically administered adrenergic agonists, epidermal keratinocytes themselves can synthesize catecholamine ligands. They also respond to these systemic or self-generated agonists via receptor mediated signaling, resulting in altered migration, and changes in wound re-epithelialization. Endothelial cells, inflammatory cells, dermal fibroblasts, and mesenchymal stem cells, all cells that contribute to the wound repair process, express multiple subtypes of adrenergic receptors and exhibit responses that can be either contribute or impair healing-and occasionally, depending on the species and assay conditions, results can be conflicting. There is still much to be uncovered regarding how this self-contained autocrine and paracrine signaling system contributes to cutaneous wound repair.
KW - β-Adrenergic receptor
KW - Angiogenesis
KW - Dermal fibroblast
KW - Inflammation
KW - Keratinocyte migration
KW - Re-epithelialization
KW - Wound contraction
KW - Wound healing
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UR - http://www.scopus.com/inward/citedby.url?scp=53249151502&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2008.07.012
DO - 10.1016/j.phrs.2008.07.012
M3 - Article
C2 - 18790719
AN - SCOPUS:53249151502
VL - 58
SP - 158
EP - 164
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 2
ER -