αvβ6-Targeted Molecular PET/CT Imaging of the Lungs After SARS-CoV-2 Infection

Cameron C. Foster, Ryan A. Davis, Sven H. Hausner, Julie L. Sutcliffe

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The true impact and long-term damage to organs such as the lungs after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be determined. Noninvasive molecularly targeted imaging may play a critical role in aiding visualization and understanding of the systemic damage. We have identified αvβ6 as a molecular target; an epithelium-specific cell surface receptor that is low or undetectable in healthy adult epithelium but upregulated in select injured tissues, including fibrotic lung. Herein we report the first human PET/CT images using the integrin αvβ6-binding peptide (18F-αvβ6-BP) in a patient 2 mo after the acute phase of infection. Minimal uptake of 18F-αvβ6-BP was noted in normal lung parenchyma, with uptake being elevated in areas corresponding to opacities on CT. This case suggests that 18F-αvβ6-BP PET/CT is a promising noninvasive approach to identify the presence and potentially monitor the persistence and progression of lung damage.

Original languageEnglish (US)
Pages (from-to)1717-1719
Number of pages3
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume61
Issue number12
DOIs
StatePublished - Dec 1 2020

Keywords

  • fibrosis
  • integrins
  • peptides
  • positron emission tomography
  • SARS-CoV-2

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'α<sub>v</sub>β<sub>6</sub>-Targeted Molecular PET/CT Imaging of the Lungs After SARS-CoV-2 Infection'. Together they form a unique fingerprint.

Cite this