α7 nicotinic receptor subunits are not necessary for hippocampal- dependent learning or sensorimotor gating: A behavioral characterization of Acra7-deficient mice

Richard Paylor, Michelle Nguyen, Jacqueline Crawley, James Patrick, Arthur Beaudet, Avi Orr-Urtreger

Research output: Contribution to journalArticle

261 Scopus citations

Abstract

The α7 nicotinic acetylcholine receptor (nAChR) subunit is abundantly expressed in the hippocampus and contributes to hippocampal cholinergic synaptic transmission suggesting that it may contribute to learning and memory. There is also evidence for an association between levels of α7 nAChR and in sensorimotor gating impairments. To examine the role of α7 nAChRs in learning and memory and sensorimotor gating, Acra 7 homozygous mutant mice and their wild-type littermates were tested in a Pavlovian conditioned fear test, for spatial learning in the Morris water task, and in the prepulse inhibition paradigm. Exploratory activity, motor coordination, and startle habituation were also evaluated. Acra7 mutant mice displayed the same levels of contextual and auditory-cue condition fear as wild-type mice. Similarly, there were no differences in spatial learning performance between mutant and wild-type mice. Finally, Acra7 mutant and wild-type mice displayed similar levels of prepulse inhibition. Other behavioral responses in Acra7 mutant mice were also normal, except for an anxiety-related behavior in the open- field test. The results of this study show that the absence of 57 nAChRs has little impact on normal, base-line behavioral responses. Future studies will examine the contribution of 57 nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments.

Original languageEnglish (US)
Pages (from-to)302-316
Number of pages15
JournalLearning and Memory
Volume5
Issue number4-5
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'α7 nicotinic receptor subunits are not necessary for hippocampal- dependent learning or sensorimotor gating: A behavioral characterization of Acra7-deficient mice'. Together they form a unique fingerprint.

  • Cite this