α-tocopherol and atherosclerosis

Nalini Kaul, Sridevi Devaraj, Ishwarlal Jialal

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in the Western world. There is compelling evidence incriminating oxidative stress in the pathogenesis of the atherosclerotic lesion. Several lines of evidence suggest that antioxidants, especially α-tocopherol, have potential beneficial effects with regard to cardiovascular disease. In vitro, α-tocopherol has been shown to inhibit platelet adhesion and aggregation and smooth muscle cell proliferation, exert anti-inflammatory effects on monocytes, and improve endothelial function. Also, supplementation with α-tocopherol has been shown to decrease lipid peroxidation, platelet aggregation, and pro-inflammatory activity of monocytes. However, clinical trials with α-tocopherol supplementation to date have been equivocal. Thus, although mounting in vitro evidence and animal models provide a sound scientific basis for α-tocopherol supplementation, further clinical trials are required before a definitive recommendation can be made with respect to the primary and secondary prevention of heart disease.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume226
Issue number1
StatePublished - 2001
Externally publishedYes

Keywords

  • α-tocopherol
  • Antioxidant
  • Atherosclerosis
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'α-tocopherol and atherosclerosis'. Together they form a unique fingerprint.

  • Cite this