α- and γ-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice

Sang Kyu Park, Grier P. Page, Kyoungmi Kim, David B. Allison, Mohsen Meydani, Richard Weindruch, Tomas A. Prolla

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We used high-density oligonucleotide arrays to measure transcriptional alterations in the heart and brain (neocortex) of 30-mo-old B6C3F1 mice supplemented with α-tocopherol (αT) and γ-tocopherol (γT) since middle age (15 mo). Gene expression profiles were obtained from 5- and 30-mo-old control mice and 30-mo-old mice supplemented with αT (1 g/kg) or a mixture of αT and γT (500 mg/kg of each tocopherol) from middle age (15 mo). In the heart, both tocopherol-supplemented diets were effective in inhibiting the expression of genes previously associated with cardiomyocyte hypertrophy and increased innate immunity. In the brain, induction of genes encoding ribosomal proteins and proteins involved in ATP biosynthesis was observed with aging and was markedly prevented by the mixture of αT and γT supplementation but not by αT alone. These resultsdemonstrate that middle age-onset dietary supplementation with αT and γT can partially prevent age-associated transcriptional changes and that these effects are tissue and tocopherol specific.

Original languageEnglish (US)
Pages (from-to)1010-1018
Number of pages9
JournalJournal of Nutrition
Volume138
Issue number6
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Tocopherols
tocopherols
heart
brain
mice
Brain
neocortex
gene expression
Ribosomal Proteins
gene induction
Neocortex
ribosomal proteins
Dietary Supplements
oligonucleotides
Oligonucleotide Array Sequence Analysis
hypertrophy
Transcriptome
Age of Onset
Cardiac Myocytes
Innate Immunity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Park, S. K., Page, G. P., Kim, K., Allison, D. B., Meydani, M., Weindruch, R., & Prolla, T. A. (2008). α- and γ-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. Journal of Nutrition, 138(6), 1010-1018.

α- and γ-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. / Park, Sang Kyu; Page, Grier P.; Kim, Kyoungmi; Allison, David B.; Meydani, Mohsen; Weindruch, Richard; Prolla, Tomas A.

In: Journal of Nutrition, Vol. 138, No. 6, 06.2008, p. 1010-1018.

Research output: Contribution to journalArticle

Park, SK, Page, GP, Kim, K, Allison, DB, Meydani, M, Weindruch, R & Prolla, TA 2008, 'α- and γ-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice', Journal of Nutrition, vol. 138, no. 6, pp. 1010-1018.
Park SK, Page GP, Kim K, Allison DB, Meydani M, Weindruch R et al. α- and γ-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. Journal of Nutrition. 2008 Jun;138(6):1010-1018.
Park, Sang Kyu ; Page, Grier P. ; Kim, Kyoungmi ; Allison, David B. ; Meydani, Mohsen ; Weindruch, Richard ; Prolla, Tomas A. / α- and γ-tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. In: Journal of Nutrition. 2008 ; Vol. 138, No. 6. pp. 1010-1018.
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