Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease

Project: Research project

Description

DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is characterized by acute clinical manifestations, including painful crisis, acute chest syndrome, priapism, and stroke, as well as chronic irreversible damage to the heart, lungs, kidneys, eyes, spleen and femoral heads. Vascular injury and occlusion, primarily affecting the microvasculature, underlie most of these complications. Another characteristic of sickle cell patients, both adult and pediatric, is a high prevalence of low vitamin B6 status (exceeding 50%), as indicated by low plasma pyridoxal-5'- phosphate levels (
StatusFinished
Effective start/end date4/15/073/31/12

Funding

  • National Institutes of Health: $363,197.00
  • National Institutes of Health: $363,470.00
  • National Institutes of Health: $363,470.00
  • National Institutes of Health: $363,470.00

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Acute Chest Syndrome
Priapism
Vitamin B 6
Pyridoxal Phosphate
Vascular System Injuries
Sickle Cell Anemia
Thigh
Microvessels
Blood Vessels
Spleen
Stroke
Pediatrics
Kidney
Lung

ASJC

  • Medicine(all)