Project: Research project

Project Details


The California Regional Primate Research Center (CRPRC) is currently
equipped with an ATL MK 600 which was purchased new in 1984. In order to
continue to provide state-of-the-art sonographic support for a variety of
NIH-funded studies, a new unit with the current technological advances is
required. For our purposes, the improvements in image quality, variety of
transducer options, expansion of pulsed Doppler features, in addition to
the availability of color Doppler imaging (CDI) would allow us to enhance
and expand our current research focus. In addition, CDI would provide an
additional means for evaluating maternal/fetal/placental interactions, an
area that has not been fully explored. A variety of studies related to
developmental and reproductive biology using the nonhuman primate (macaque)
as a model for the human are performed at the CRPRC. We have established
a substantial ultrasound program specifically related to the reproductive
biology of the macaque with defined growth charts for a variety of
biometric parameters, methods for evaluating embryonic and fetal normal and
abnormal growth and development, in addition to a number of ultrasound-
guided interventional procedures for both gravid and nongravid female
macaques. We have the capabilities to access both the embryo and fetus
with ultrasound-guidance, thus eliminating the need for surgical
procedures. These techniques and procedures are incorporated in all
studies of a reproductive nature performed at the CRPRC. Our overall
Center aim is to utilize the nonhuman primate as a model to investigate
those areas that cannot be ethically explored in the human with the intent
of applying learned information and techniques to the human clinical
setting. Projects currently in progress at the CRPRC with NIH funding
include: (1) studies to determine the potential pre- and postnatal
bioeffects of prenatal ultrasound exposure (#HD25528), (2) mechanisms of
action and effects of treatment of fetal and neonatal macaques with
epidermal growth factor (EGF) (#HD24959), and (3) the development of rhesus
models for in utero hematopoietic stem cell (HSC) transplantation utilizing
(a) adult T-cell depleted bone marrow (#AI29512) and (b) fetal liver
(#HL39875). All of the above in addition to several studies supported by
the CRPRC base grant (#RR00169) and an NICHD contract (#HD3-2804) would
benefit from the incorporation of a new ultrasound unit. It would provide
the ability to enhance, expand, and complement our current research
interests in addition to promote new avenues of focus and potential
Effective start/end date9/30/919/29/92


  • National Institutes of Health


  • Medicine(all)


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