UC DAVIS ALZHEIMERS DISEASE CENTER CORE

Project: Research project

Project Details

Description

The UC Davis Alzheimer's Disease Center (ADCC) represents a collaborative
effort by investigators and clinicians at the University of California,
Davis and the Lawrence Berkeley Laboratory. For the past 5 years, these
groups have been working together using a variety of techniques to study
patients with Alzheimer's disease (AD). The overall scientific goal of
this program, relating the neurobehavioral features of the disease to its
neurobiology, will be advanced by the ADCC, which will integrate and expand
a host of clinical and research activities currently ongoing. Important
aspects of the program include careful and uniform cognitive and behavioral
evaluations of a large cohort of patients and control subjects, yearly
longitudinal follow-up, ultimate neuropathological examination, and
management of a data base containing all of this information. The program will utilize 5 existing clinics to refer patients to the ADCC.
Two of these referral clinics with a long history of collaboration are
State of California funded Alzheimer's Disease Diagnostic and Treatment
Centers (ADDTCs), located in Berkeley and Sacramento. Patients will also
be referred from two county hospital clinics and a VA hospital clinic.
This integrated network will make the ADCC accessible to a large and
diverse population extending from the San Francisco Bay Area through the
Central Valley to the Sierra Foothills and the Oregon border. In order to
accommodate this large geographic catchment area, the ADCC will have two
clinical performance sites in Berkeley and Sacramento, utilizing shared
personnel and joint training and clinical activities to ensure uniformity
of data collection. This system will be supervised by a centralized
administrative core to ensure maintenance of clinical, programmatic, and
scientific goals. Clinical data, comprising the results of the history, physical and
neurological examination, laboratory evaluation, neuroimaging results, and
the detailed behavioral and cognitive assessment, will be collected, coded,
stored, and analyzed uniformly. This data base, available to all
investigators, will greatly enhance the capacity for collaborative
projects. Neuropathological examination will be ensured by longitudinal
follow-up and enhancement of a system which has already proven effective.
Autopsy services will be provided locally, with quickly dispatched
dissectors available to process tissue for a number of types of studies.
All tissue will be studied in Sacramento, with detailed and quantitative
neuropathological results entered into the data base. Tissue processed in
a number of ways will also be available to investigators. These collective functions of the ADCC will be enhanced through activities
focused upon training researchers and clinicians, promoting the ADCC within
the University and community in order to recruit new investigators and
patients, and increasing interactions between researchers, clinicians, and
members of the University community in general.
StatusActive
Effective start/end date9/30/916/30/21

Funding

  • National Institutes of Health: $1,224,368.00
  • National Institutes of Health
  • National Institutes of Health: $1,281,674.00
  • National Institutes of Health: $155,500.00
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  • National Institutes of Health: $61,876.00
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  • National Institutes of Health: $1,312,222.00
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  • National Institutes of Health: $51,048.00
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  • National Institutes of Health: $84,342.00
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  • National Institutes of Health: $63,000.00
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  • National Institutes of Health: $1,242,805.00
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  • National Institutes of Health: $1,223,034.00
  • National Institutes of Health: $1,387,358.00
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  • National Institutes of Health: $1,388,896.00
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  • National Institutes of Health: $2,000.00
  • National Institutes of Health: $1,162,202.00
  • National Institutes of Health: $63,000.00
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  • National Institutes of Health: $1,316,415.00
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  • National Institutes of Health: $37,184.00
  • National Institutes of Health: $1,257,815.00
  • National Institutes of Health
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  • National Institutes of Health: $1,218,619.00
  • National Institutes of Health: $1,274,316.00
  • National Institutes of Health
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  • National Institutes of Health: $75,502.00
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  • National Institutes of Health: $1,278,076.00
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  • National Institutes of Health: $1,192,537.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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