The relationship between epidermal growth factor receptor and hedgehog signaling

Project: Research project

Description

DESCRIPTION (provided by applicant): It is estimated that over 140,000 people in the United States will be diagnosed with cancer of the colon and rectum and approximately 51,000 deaths will occur from this disease in 2010. The majority of colon cancer-related deaths can be attributed to metastasis. Therefore, a better understanding of the metastatic process may lead to prognostic and therapeutic advancements. Epidermal growth factor receptor (EGF-R) and Hedgehog (Hh) signaling pathways are independently known to contribute to the development or progression of many cancers including malignancies of the skin, brain, lung, breast, prostate, pancreas, ovary, and colon. Several studies now support the notion that bi- directional cross-talk between Hh and EGF-R can dramatically alter the cellular effects of either pathway alone. However, the implication of these complex interactions in regard to the development, progression, prognosis, and treatment of cancer remain largely unexplored. The goal of this research plan is to determine the contribution of EGF-R and Hh signaling interactions to the progression and metastasis of human colon cancer cells. The specific aims are to 1) Determine the effects of EGF-R on Hh mediated colon cancer cell signaling, growth, and survival, and to 2) Determine how EGF-R and Hh signaling modulates growth, survival, and spontaneous metastasis of human colon cancer cells growing orthotopically in mice. The K01 award would support Dr. Rebhun's career development and will further prepare him for an independent research career in comparative and translational cancer research. Dr. Rebhun is a board certified clinical veterinary oncologist (DVM, Diplomate ACVIM-Oncology) and is a dual-trained clinician/scientist with a Ph.D. degree in cancer biology. Five years of mentored support is requested.
StatusFinished
Effective start/end date7/15/115/31/16

Funding

  • National Institutes of Health: $130,950.00
  • National Institutes of Health: $124,534.00
  • National Institutes of Health: $130,950.00
  • National Institutes of Health: $130,950.00

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Hedgehogs
Epidermal Growth Factor Receptor
Colonic Neoplasms
Neoplasms
Neoplasm Metastasis
Translational Medical Research
Survival
Rectal Neoplasms
Growth
Research
Prostate
Pancreas
Ovary
Colon
Breast
Lung
Skin
Brain
Therapeutics

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)