The Identity/Role of IP3 Receptor Associated Proteins

  • Patterson, Randen L (PI)

Project: Research project

Project Details


DESCRIPTION (provided by applicant):
Vesicle trafficking of neurotransmitters, neuronal response to nitric oxide,
and SOCaE are critical functions in neurons. The InsP3-R may be a crucial
regulator of these processes (see sec 30b). Binding partners of the InsP3-R
that we identify may modulate such regulation. Recent work in this field has
demonstrated that the InsP3-R is a central entity in many Ca2+ signaling
pathways in neuronal systems. Identification of the microenvironment of
proteins in which the InsP3-R resides will further our knowledge of InsP3-R,
and its binding partners involvement within in neuronal signaling pathways.
Additionally it will increase our knowledge of how the InsP3-R is able to
discriminate between the many pathways that converge on its activity.
The main objective of this proposal is to examine the role of the InsP3-R and
InsP3-R signaling pathways in neurons. Specifically I intend to identify
binding partners for the InsP3-R, and examine their roles in neurotransmitter
secretion, SOCaE, and regulation of the InsP3-R itself.
Effective start/end date9/16/02 → …


  • National Institutes of Health: $33,260.00
  • National Institutes of Health: $46,420.00
  • National Institutes of Health: $38,320.00


  • Medicine(all)


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