SUBSTRATUM TOPOGRAPHY EFFECTS ON CORNEAL EPITHELIUM

Project: Research project

Project Details

Description

DESCRIPTION: Basement membranes have many features which greatly influence cell function including specific proteins and functional groups, a reservoir of growth factors and other trophic agents, and a complex three-dimensional topography into which adherent cells extend processes and to which cells form adhesion plaques. The three dimensional topography of the underlying substrate, independent of specific receptor-ligand interactions, has been recently shown to influence fundamental cell behaviors. The majority of studies conducted to date have evaluated the effect of large scale (>1um) features on cell behavior. The relevance of these "large scale" studies to cell behavior in vivo is not clear since the PI's laboratories have shown the basement membrane underlying the anterior corneal epithelium to consist of a complex 3-dimensional nanoscale (>1um feature size) architecture which amplifies its surface area for cell-membrane interaction approx. 3500-4000 fold. The overall purpose of this proposal is to investigate the influence of nonoscale (
StatusFinished
Effective start/end date7/1/9812/31/06

Funding

  • National Institutes of Health
  • National Institutes of Health: $327,375.00
  • National Institutes of Health: $188,110.00
  • National Institutes of Health: $327,375.00
  • National Institutes of Health: $327,375.00
  • National Institutes of Health: $327,375.00
  • National Institutes of Health: $193,455.00
  • National Institutes of Health

ASJC

  • Medicine(all)

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