STUDIES OF NEURONAL SPECIFICITY IN THE HIPPOCAMPUS

Project: Research project

Description

The proposed work is both a continuation and an extension of the studies
that we have been engaged in for some years. The longterm objectives of
this work are to provide as complete an analysis of the organization and
development of the hippocampal formation as possible, and, by taking
advantage of the unusual simplicity of these cortical areas, to provide a
model for understanding the development of cortical areas in general. In
the coming grant period we plan to focus our attention on several specific
problems associated with the development of the dentate gyrus, the
structural organization of which is sufficiently well known (in large part
from our own earlier studies) to enable us to address a number of
fundamental questions concerning cortical development. These include: (1)
Analyzing in detail three-dimensional morphology of individual dentate
granule cells to establish on a quantitative basis the degree of
variability in such cells; (2) Examining, again quantitatively, the
development of these neurons both in vivo and in vitro; (3) To determine,
using a variety of immunocytochemical procedures, the unusual pattern of
migration of the dentate granule cells; (4) To reexamine the origin of the
glial cells in the dentate gyrus; (5) To examine the role played by the
so-called nerve cell adhesion molecule (nCAM) in the assembly of the
dentate gyrus and in the initial formation of its connections; and (6) To
use the dentate gyrus to screen for the expression of a variety of cellular
oncogenes during normal development, and to determine if some of these
genes are reactivated during the reactive synaptogenesis that occurs in the
dentate when it is deprived of certain of its afferent inputs.
StatusFinished
Effective start/end date7/1/801/31/17

Funding

  • National Institutes of Health: $370,938.00
  • National Institutes of Health: $369,063.00
  • National Institutes of Health
  • National Institutes of Health: $511,055.00
  • National Institutes of Health: $534,485.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $583,541.00
  • National Institutes of Health: $509,748.00
  • National Institutes of Health
  • National Institutes of Health: $545,311.00
  • National Institutes of Health: $427,725.00
  • National Institutes of Health: $497,399.00
  • National Institutes of Health: $567,254.00
  • National Institutes of Health: $50,000.00
  • National Institutes of Health
  • National Institutes of Health: $40,610.00
  • National Institutes of Health: $361,546.00
  • National Institutes of Health: $277,220.00
  • National Institutes of Health: $328,635.00
  • National Institutes of Health
  • National Institutes of Health: $179,201.00
  • National Institutes of Health
  • National Institutes of Health: $494,678.00
  • National Institutes of Health: $371,250.00
  • National Institutes of Health
  • National Institutes of Health: $484,020.00

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Hippocampus
Haplorhini
Primates
Dentate Gyrus
Neurons
Temporal Lobe
Entorhinal Cortex
Perforant Pathway
Brain
Macaca mulatta
Neuroanatomy
Parahippocampal Gyrus
Long-Term Memory
Research
Organizations
Neurogenesis

ASJC

  • Medicine(all)
  • Neuroscience(all)