STRENGTH AND MICRO-STRAIN IN VERTEBRAL TRABECULAR BONE

Project: Research project

Project Details

Description

DESCRIPTION: The architectural
influences on vertebral cancellous bone strength and the effect of applied
stresses on cancellous bone remodeling are not well understood. One reason
for this is that the transmission of stress through cancellous bone has not
been extensively investigated at the trabecular level. At this time, there
is no theoretical model for cancellous bone that properly reproduces both
the morphologic and mechanical aspects of this tissue. A mechanical model of cancellous bone is needed which: matches all
standard stereological measures of trabecular hard tissue morphology;
accurately predicts bone strength and stiffness in 3D; and also accurately
predicts the tissue level stresses and strains. The development of this
model is here in proposed. Advanced numerical methods for stress analysis
of cellular structures will be used to define the basic model, and it will
be validated by comparison of: (1) model predictions of stiffness and
strength with experimental results for vertebral cancellous bone; (2) model
predictions of structural failure pattern with actual failure patterns; and
(3) model predictions of trabecular stress and strain with
three-dimensional finite element stress analysis predictions of trabecular
stress and strain. Development of this model will provide a basic tool for the understanding
of cancellous bone remodeling and strength. It will be valuable for the
examination of the effects of bone remodeling on vertebral bone strength
and it will increase the understanding of the mechanical causes of
vertebral collapse in osteopenic women.
StatusFinished
Effective start/end date7/1/913/31/12

Funding

  • National Institutes of Health: $189,153.00
  • National Institutes of Health: $84,400.00
  • National Institutes of Health
  • National Institutes of Health: $191,083.00
  • National Institutes of Health: $193,014.00
  • National Institutes of Health: $187,972.00
  • National Institutes of Health
  • National Institutes of Health: $200,765.00
  • National Institutes of Health
  • National Institutes of Health: $193,014.00
  • National Institutes of Health
  • National Institutes of Health: $120,000.00
  • National Institutes of Health: $91,378.00
  • National Institutes of Health
  • National Institutes of Health: $97,082.00
  • National Institutes of Health
  • National Institutes of Health: $202,558.00
  • National Institutes of Health: $200,156.00

ASJC

  • Medicine(all)

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