ROLE OF LEUKOCYTE ADHESION RECEPTORS IN THE PATHOBIOLOGY

Project: Research project

Project Details

Description

DESCRIPTION: The central hypothesis of
this application is that leukocyte adhesion receptors play crucial roles in
a number of aspects of the biology of human immunodeficiency virus (HIV)
and simian immunodeficiency virus (SIV), including infectivity, tropism and
cytopathicity. The first specific aim of the project is to try to
establish in vitro HIV and SIV infectivity assays in which cell-to-cell
transmission predominates. Next, the applicant proposes to characterize
the role of leukocyte adhesion molecules in transmission of HIV and SIV and
to characterize the role of these molecules in induction of HIV expression.
The fourth goal of the project is to evaluate the potential contribution of
leukocyte adhesion molecules to the tropism of HIV and SIV. The last goal
of the applicant is to try to characterize the effect of HIV infection on
the expression and function of leukocyte adhesion molecules. The
investigator proposes to use monoclonal antibodies and other probes to
examine the role of adhesion molecules in virus transmission in the
presence of agents such as azidothymidine (AZT) and interferon-alpha which
block infection by free virus. He also proposes using vif-defective HIV
which infects poorly as free virus but infects in cell-to-cell transmission
assays. Leukocyte function assays and Northern blot analysis will be used
to study the effect of HIV and SIV infection on expression and function of
adhesion molecules.
StatusFinished
Effective start/end date9/1/911/31/05

Funding

  • National Institutes of Health: $409,271.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $294,907.00
  • National Institutes of Health: $123,000.00
  • National Institutes of Health: $498,750.00
  • National Institutes of Health
  • National Institutes of Health: $205,000.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $160,615.00
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)

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