RNA-SPECIFIC LIGANDS: AN APPROACH TO NEW ANTIVIRALS

  • Beal, Peter A, (PI)

Project: Research project

Description

DESCRIPTION: Ribonucleic acid (RNA) function is central to all life, including that of viruses and bacteria. Antibacterial agents such as neomycin and erythromycin are examples of existing drugs that target sites in bacterial ribosomal RNAs. Unfortunately, bacteria are becoming increasingly resistant to these compounds via adaptation that allows for the modification of the RNA target or modification of the antibiotic. Human immunodeficiency virus (HIV), adenovirus (AV) and Epstein-Barr virus (EBV) are examples of human pathogens that all have unique RNA structures that appear necessary for replication. Each of these RNAs are potential targets for drug intervention. Unfortunately, our lack of understanding of the recognition of RNA by small molecules limits our ability to design high affinity ligands. The goal of this project is to identify low molecular weight ligands (
StatusFinished
Effective start/end date1/1/018/31/05

Funding

  • National Institutes of Health: $150,000.00
  • National Institutes of Health: $150,000.00
  • National Institutes of Health: $186,875.00
  • National Institutes of Health: $149,750.00

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Antiviral Agents
RNA
Ligands
Bacterial RNA
Anti-Bacterial Agents
Bacteria
Ribosomal RNA
Neomycin
Erythromycin
Adenoviridae
Pharmaceutical Preparations
Intercalating Agents
Human Herpesvirus 4
Molecular Weight
HIV
Viruses
Peptides

Keywords

  • Medicine(all)
  • Immunology and Microbiology(all)