Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging

Project: Research project

Project Details


DESCRIPTION (provided by applicant): Over the last two decades, the use of advanced medical imaging, particularly with computed tomography (CT), has increased dramatically with over 80 million CT scans performed annually in the United States (U.S.). Integrating CT into routine care has contributed to the earlier and more accurate diagnosis of disease and injury. However, it has also markedly increased patient exposure to ionizing radiation, a well-established carcinogen. Many past studies of cancer risk have focused on specific human populations, such as Japanese atomic bomb survivors, which differ from the general US population undergoing routine medical imaging, and while most experts agree that radiation from medical imaging is associated with increased risk of cancer, the magnitude of the risk is unknown. We propose to study pregnant women and children enrolled from 1996 to 2017 in four integrated health care delivery systems: Kaiser Permanente (KP) Northern California, KP Southern California, KP Northwest, and Group Health Cooperative. We will use a stratified nested case-control study with counter-matching to comprehensively evaluate patterns of medical imaging, cumulative exposure to radiation, and subsequent risk of pediatric cancers. The cohort will include health plan members
Effective start/end date3/1/155/31/20


  • National Institutes of Health: $1,834,140.00
  • National Institutes of Health: $2,196,358.00


  • Medicine(all)


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