• Joseph, Jill G (PI)
  • Maassab, H. (PI)
  • Schwartz, Stanley (PI)
  • Maassab, Hunein (PI)
  • Ostrow, David G. (PI)

Project: Research project

Project Details


This proposal seeks three years of continued support for the Coping and
Change Study (CCS), a prospective study of behavioral and psychosocial
issues in a cohort of approximately 650 homosexual men at risk for Acquired
Immune Deficiency Syndrome (AIDS). Support from NIAID through the Chicago
Multicenter AIDS Cohort Study (MACS) provides biomedical investigations
every six months in order to document the natural history of HIV infection.
The applicants have received NIMH support since June 1985 for psychosocial
investigation of the same cohort. Over 95 percent of those participating
in the NIAID-funded study agreed to participate in the CCS. Data are
obtained by asking participants to complete a self-administered
questionnaire at home two weeks following their biannual MACS studies. The
CCS assessment focuses on sexual behavior, psychological and social
functioning, concurrent stresses (particularly those idiosyncratic to the
AIDS crisis), personal resources, and coping strategies. The simultaneous collection of biomedical and psychosocial data in the same
cohort provides a unique opportunity to continue investigating two
important research questions: 1) To what extent are behavioral risk
reduction and/or relapse occurring and what are the determinants of such
behavior in this cohort of homosexual men? Analyses to date suggest that
behavioral changes may be relatively unstable in a significant portion of
the cohort (approximately one-third) and that long-term predictive models
are difficult to identify. Nonetheless, several variables consistently
associated with long-term behavioral patterns have been identified and will
continue to be investigated as the epidemic evolves. Such prospective data
are both theoretically valuable and have important practical implications
for designing and implementing preventive interventions. 2) To what extent
is psychological or social functioning impaired in response to the threat
of AIDS and what are the determinants of such dysfunction? The crisis of
AIDS has meant the introduction of previously unanticipated and potentially
severe stressors into the lives of all those at risk. Remarkably stable
and only moderately elevated levels of psychological distress have been
described in the cohort, with the greatest impact on AIDS-specific
measures. We will continue to monitor these responses, the psychosocial
factors predictive of distress, and the inter-relationships between
psychological functioning and behavioral risk-reduction.
Effective start/end date9/30/8311/30/95


  • National Institutes of Health


  • Medicine(all)


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.