Project: Research project

Project Details


This application for a Research Career Development Award (RCDA) reflects
both the candidate's long-time interest in the effects of environmental
exposures on adverse health outcomes and a specific change in career
interest from one mainly of cancer epidemiology to one primarily of
reproductive epidemiology The RCDA will provide the candidate the
opportunity to acquire skills and knowledge in laboratory techniques and
physiology in reproductive endocrinology, conducting prospective studies
using 6-month diaries, biological markers of outcomes and exposures, and
statistical analysis of these data. The knowledge gained will have
preventive implications in meeting the challenge of identifying women at
high risk for adverse reproductive outcomes and abnormal ovarian function.
Long-term goals include developing clinical epidemiologic studies of
ovarian function and epidemiologic studies to examine the effects of
ergonomic stressors, physical activity, stress, ethnicity and environmental
exposures on ovarian function, using biologic assays of reproductive
urinary steroid hormones, and testing the validity of further refined urine
screening assays of human chorionic gonadotropin (hCG). The RCDA will thus
involve biochemical epidemiology, linking epidemiologic study data with
laboratory investigations, thus enhancing the quality and biologic
significance of the epidemiologic findings of these studies. The candidate is a co-investigator for a prospective study to follow 500
eligible women employed full-time in wafer-manufacturing jobs in the
semiconductor industry for 6 of their menstrual cycles. Women will collect
daily morning urine samples and complete a brief daily diary, covering key
points related to their menstrual cycle, daily habits and exposures at
work. A detailed telephone interview will be administered to determine any
changes in habits or status. An exit questionnaire will also be
administrated after 6 cycles. All pregnancies and pregnancy losses will be
determined by urine assays for hCG. Outcomes of pregnancies that are not
spontaneously or therapeutically aborted will be determined by contacting
the women who become pregnant after their expected date of delivery. Data
will be analyzed to determine if certain chemical, physical or ergonomic
exposures in wafer-manufacturing are associated with an increased risk of
spontaneous abortion or other adverse reproductive outcomes.
Effective start/end date12/1/778/31/95


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Environmental Science(all)
  • Medicine(all)


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