Project: Research project

Project Details


Brain tumors, the most common solid tumors of childhood, represent a
significant cause of neurological morbidity and mortality. For
medulloblastoma and other primitive neuroectodermal tumors (PNET) of the
CNS, the biology, treatment and delayed neurotoxicities are poorly
understood despite its recognized importance as the most common childhood
brain tumor. Moreover, the specialized problems posed by childhood brain
tumors are only partially addressed by current brain tumor research centers
and a more focused commitment is required. Our proposal identifies two
overall objectives designed to explore the feasibility of developing a
pediatric brain tumor research center at The Children's Hospital of
Philadelphia (CHOP). The first objective is to develop an integrated,
coordinated network of investigators who will examine laboratory and
clinical issues specific to PNET and relevant to other childhood brain
tumors. This objective will be accomplished by the Aims for the Program as
a Whole, including specific mechanisms to: (1) improve communication and
interaction between investigators; (2) attract promising young
investigators and entice established researchers to address pediatric
neuro-oncology topics; and (3) encourage trainees to pursue careers as
clinician-scientists in pediatric neuro-oncology research. The second
objective is to increase our understanding of the biology, treatment and
delayed toxicities of therapy by conducting innovative research. This
objective will be accomplished by the following exploratory projects which,
together, represent a comprehensive approach to PNET: Project 1 will
address the role of protein tyrosine kinase growth factors in PNET
differentiation and pathogenesis; Project 2 will examine signal
transduction pathways (phospholipase C) in PNET, Project 3 will evaluate
innovative therapeutic approaches to PNET and other childhood brain tumors;
Project 4 will use innovative methodologies to address the functional
biology, prevention and treatment of treatment-associated brain injury in
long-term survivors of PNET. The Neuro-Oncology Program at CHOP has
received recognition for its clinical contributions. This proposal
addresses the need for integrated program development that includes basic
sciences and experimental therapeutics. It is further enhanced by recent
events at The Children's Hospital of Philadelphia and University of
Pennsylvania, including new Program leadership, faculty recruitments, and
construction of research facilities. Together with our large brain tumor
population, institutional commitments to the specialized problems of
children, strong research environment from the surrounding University, and
on-site access to NIH-funded specialized research centers relevant to this
proposal, these strengths make CHOP an ideal site to explore the
feasibility of developing a specialized center for pediatric brain tumor
Effective start/end date9/30/929/29/95


  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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