PATHOGENESIS OF PERSISTENT VIRAL INJURY TO THE CNS

  • Pleasure, David E (PI)
  • Lavi, Ehud (PI)
  • Cohen, Gary (PI)
  • Gaulton, Glen (PI)
  • Weiss, Susan R. (PI)
  • Eisenberg, Roselyn J. (PI)
  • Gonzalez-Scarano, Francisco (PI)

Project: Research project

Description

This proposal brings together a group of investigators with expertise in
different viral systems and centers around the common theme of
interactions of viruses with the nervous system. The overall goal is a
better understanding of the relationships between viral proteins and the
determinants of neural cell differentiation, particularly as they relate
to viral tropism and viral pathology. The proposal contains 5 major components: 4 projects and 1 core. In
project I, Dr. Gonzalez-Scarano will look at the interaction of two HIV
viral proteins with neural cells and neural cell components; in project
II, Dr. Gaulton will study the neuropathology of Gross murine leukemia
virus; in project III, Dr. Weiss will study the cytopathology of murine
coronaviruses in neural cells, with particular emphasis on the fusion
process; in project IV Drs. Eisenberg and Cohen will identify the
receptor molecule(s) responsible for Herpes Simplex entry into nervous
system cells. Dr. Pleasure will direct a cell culture core that will
provide specialized cells and analytical expertise to all of the
component projects. The findings from each of these component projects will enhance our
understanding of neurologic dysfunction mediated by viruses, and will
have applicability to the study of multiple sclerosis, viral encephalitis
and AIDS.
StatusFinished
Effective start/end date1/1/936/30/04

Funding

  • National Institutes of Health
  • National Institutes of Health

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Cell Culture Techniques
Viral Tropism
Viruses
Herpes Simplex
Pleasure
Viral Proteins
Cellular Structures
Neurologic Manifestations
Nervous System
Multiple Sclerosis
Cell Differentiation
Acquired Immunodeficiency Syndrome
Research Personnel
Pathology
Proteins

ASJC

  • Medicine(all)
  • Neuroscience(all)