North-Central California-Center For AIDS Research

Project: Research project

Project Details


DESCRIPTION (Provided by applicant): Two geographically and
scientifically linked institutions in North-Central California will establish
a Developmental Center for AIDS Research (D-CFAR) that will benefit all of the
investigators and clinicians at the respective institutions, as well as the
patients living inside and outside that region. This D-CFAR will put into
place the appropriate infrastructure and leadership needed to successfully
compete for funding as a full CFAR in a 3-year time frame. This North-Central
California Developmental CFAR (NCCFAR) will capitalize on the complementary
strengths of the institutions, UC Davis and the Virology and Rickettsial
Diagnostic Laboratory of the California Department of Health Services
(VRDL/CDHS), and fill the gaps needed to develop a full CFAR. At that time a
third administratively linked institution, UC Berkeley, will be added to the
overall Center. The overall aims of the NCCFAR will be to concentrate efforts
during the first years of funding in three specific emphasis areas. The first
will be to study prevention strategies along with investigations aimed at
developing an effective HIV-1 vaccine. The second will be to gain a better
understanding of disease pathogenesis using investigations that span the
basic, preclinical and clinical arenas. The third will be to translate
knowledge gained from the basic science and preclinical components of the
program into developing potential new treatment or prevention modalities. All
three of the aims will be carried out in the context of improving the
preventative and patient care delivered to local populations. The NCCFAR will
be developed using five cores that emphasize the strengths of the relative
institutions. The NCCFAR will be organized and led by the Administrative Core
at UC Davis. Pilot projects and support for new investigators and science will
be funded through a Developmental Core. A basic science Primate Core will be
based at the California Regional Primate Facility at UC Davis. A Virology and
Immunology Core, located at the VRDL/CDHS, will focus on supplying the basic
and clinical virology and immunology infrastructure that will benefit
individual investigators, as well as allow for the conduct of complex clinical
trials. Lastly, a Clinical Core will be established to conduct clinical
trials, perform translational research and supply patient-based samples.
Effective start/end date9/18/017/31/06


  • National Institutes of Health
  • National Institutes of Health: $732,522.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $801,832.00
  • National Institutes of Health


  • Medicine(all)
  • Immunology and Microbiology(all)


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