Project: Research project

Project Details


During the 60 msec which follow the delivery of auditory signals, neural
messages travel from the brainstem to auditory cortex and association
areas. Coterminously, a series of electical deflections -- the
middle-latency auditory evoked potentials (MAEPs) -- appear over the
fronto-central scalp. Due to their great sensitivity to auditory
processing of tones across the audiometric spectrum, MAEPs could play an
important role in audiological diagnosis. They could also help to clarify
the contribution of forebrain systems in normal hearing, and aid in
diagnosing structural damage to these systems. However, the utilization of
MAEPs remains hampered by a lack of understanding of their fundamental
properties. Herein, we propose a series of experiments to clarify their
functional properties and neuroanatomical generators, and to elucidate the
stimulation and recording procedures necessary for further clinical and
research applications. These experiments are designed to answer the
following questions: 1) What stimulus features elicit MAEPs? Which MAEP
components are produced by stimulus offset, changes in sutmulus frequency,
or changes in the apparent spatial position of tones? Which components
show binaural interaction? 2) What are the scalp distributions of MAEP
components? Do the distributions change with changes in tone frequency
and/or ear of stimulus delivery? 3) What are the characteristics of
adaptation which occur when stimuli are repeated at very high rates? Do
scalp distributions changes during adaptation? 4) What are the auditory
processes indexed by different MAEP components? What specificity of
adaptation is observed when certain attributes of the stimulus are repeated
and others are varied? 5) What are the neuroanatomical generators of the
MAEP? How are MAEPs affected by lesions of the neocortex or diencephalon?
Effective start/end date4/1/833/31/86


  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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