MICROTUBULE BASED TRANSPORT IN EARLY EMBRYOS

  • Scholey, Jonathan M, (PI)

Project: Research project

Project Details

Description

DESCRIPTION: This application is focused on the analysis of mechanisms and functions of MT-based motors that the investigators postulate drive specific transport event that occurs during early development. They propose to : 1) characterize the structure, function and domain organization of a putative minus-end-directed kinesin holoenzyme and to analyze its role in nuclear transport and mitosis; 2) to further analyze structure-function relationships in the morphogenesis and function of mitotic spindles; 3) to biochemically characterize the vesicular cargo of the sea urchin embryonic mitotic spindle for delivery to different destinations and 4) to purify the Drosophila Nod chromosomal kinesin-like motor from transgenic fly lines, in order to analyze the mechanism by which it transports chromosomes along MTs.
StatusFinished
Effective start/end date7/1/976/30/15

Funding

  • National Institutes of Health: $297,000.00
  • National Institutes of Health
  • National Institutes of Health: $410,878.00
  • National Institutes of Health: $297,000.00
  • National Institutes of Health: $304,568.00
  • National Institutes of Health
  • National Institutes of Health: $314,416.00
  • National Institutes of Health: $256,118.00
  • National Institutes of Health: $296,000.00
  • National Institutes of Health: $301,400.00
  • National Institutes of Health: $297,000.00
  • National Institutes of Health: $457,818.00
  • National Institutes of Health: $55,769.00
  • National Institutes of Health: $302,984.00
  • National Institutes of Health: $15,242.00
  • National Institutes of Health: $446,858.00
  • National Institutes of Health
  • National Institutes of Health: $443,709.00
  • National Institutes of Health: $87,314.00

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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