Mechanisms of protection from, and enhanced susceptibility to, HIV infection afte

Project: Research project

Description

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The key to understanding the results of the STEP/Phambili trials is first to model the results of the trial in controlled experiments using mucosal SIV inoculation of rhesus macaques. Thus, we will determine the effectiveness and potential of the Merck trivalent HIV adenovirus 5 vector vaccine (V520) for enhancing susceptibility to S1V in a rhesus macaque model of mucosal HIV transmission. If models of vaccine protection or enhancement are established, the immune mechanisms and inflammation/activation associated with any protective or enhancing effects can be defined in a renewal application.
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StatusFinished
Effective start/end date8/14/097/31/11

Funding

  • National Institutes of Health: $1,795,378.00
  • National Institutes of Health: $2,294,327.00

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Macaca mulatta
HIV Infections
Vaccines
HIV
Adenoviridae
Inflammation

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)