LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION

Project: Research project

Project Details

Description

Collagen crosslinking will be characterized in tendon, bone, skin,
cartilage and lungs of rats. Using newly developed HPLC techniques for
separation and quantitation of reduced and of nonreducible crosslinks, we
intend to study turnover of different crosslinks in vivo.
Precursor-product relationships will be defined in different tissues
containing different collagen types. We will specifically test the
hypothesis that certain key crosslinks are markers of the ultimate
metabolic fate of collagen-degradation or deposition as fibers. Maturation
of difunctional crosslinks to tri- and tetrafunctional products will be
closely examined to ascertain the role of nonreducible crosslinks in the
maturation process. These studies should allow us to begin to understand
aspects of collagen deposition in the extracellular matrix of the lung in
normal animals, and should serve as the requisite data base to allow
systematic study of aberrations in these processes secondary to
pathophysiology and disease.
StatusFinished
Effective start/end date4/1/853/31/94

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.