LIFESTYLE AND OVARIAN FUNCTION IN MID-LIFE WOMEN

Project: Research project

Project Details

Description

Over the next two decades, nearly 40 million American women will
experience menopause, with half a million women being added to the
midlife population each year for the rest of this decade. Despite
the fact that menopause is a universal female phenomenon that
affects millions of women and costs billions of dollars in health
care resources each year, it is incompletely understood. The
effects of lifestyle, sociocultural, dietary, and psychological
factors on occurrence of menopausal symptoms and on changes in
ovarian function that accompany menopause have largely not been
well-studied. In the present research, we propose to: 1) study the relationships
of diet, body mass and body composition, physical activity, active
and passive smoking, occupational and reproductive factors, and
psychological and socio-cultural factors to risk of experiencing
menopausal symptoms, age at onset of the peri-menopause and to
changes ovarian function; 2) study the relationships between
ovarian function, body composition and bone density; and 3)
identify factors associated with successful strategies for managing
and minimizing peri-menopausal symptoms. We will recruit 200
Chinese-American women and 200 Caucasian women, aged 43-48 years,
from the membership of the Kaiser Permanente Medical Care Program
in San Francisco. At baseline, all eligible, willing participants
will be complete: a detailed in-person interview (including
questions on demographic, reproductive, medical and occupational
factors and degree of acculturation) with a bicultural, bilingual
interviewer; weight and body composition measurements; blood draw
for serum estrogen, gonadotropins, androgens and lipids; bone
densitometry; a self-administered dietary questionnaire; a self-
administered personality and psychological profile; and two
complete menstrual cycles of daily urine collection to measure
urinary metabolites of estrogen and progesterone and gonadotropins.
Women will be followed for at least two years using: weekly urine
sample collection to monitor changes in urinary metabolites of
steroid hormones and gonadotropins; daily diary collection for
information about menstrual bleeding patterns, menopausal symptoms,
illnesses, medications, nutritional supplements, smoking and
exercise; annual telephone questionnaires to detect changes in
lifestyle characteristics; annual two-cycle daily urine collection;
annual weight, body composition and bone densitometry measurements;
and annual blood sampling for estrogen, gonadotropins, androgens,
and lipids. In collaboration with the other clinical centers, we hope to answer
a number of the many outstanding questions regarding the role of
lifestyle, socio-cultural factors and ovarian function in the risk
of age at onset of perimenopause, risk of experiencing symptoms and
subsequent disease risk.
StatusFinished
Effective start/end date9/30/946/30/19

Funding

  • National Institutes of Health
  • National Institutes of Health: $674,612.00
  • National Institutes of Health: $680,958.00
  • National Institutes of Health: $782,557.00
  • National Institutes of Health: $765,606.00
  • National Institutes of Health
  • National Institutes of Health: $661,400.00
  • National Institutes of Health: $761,255.00
  • National Institutes of Health: $242,026.00
  • National Institutes of Health: $769,098.00
  • National Institutes of Health: $803,345.00
  • National Institutes of Health: $265,894.00
  • National Institutes of Health: $720,809.00
  • National Institutes of Health: $746,508.00
  • National Institutes of Health: $476,223.00
  • National Institutes of Health: $806,674.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $811,055.00
  • National Institutes of Health: $578,208.00
  • National Institutes of Health: $789,885.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $70,081.00
  • National Institutes of Health
  • National Institutes of Health: $775,182.00
  • National Institutes of Health: $483,007.00
  • National Institutes of Health
  • National Institutes of Health: $14,863.00

ASJC

  • Medicine(all)

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