INTERDISCIPLINARY STUDIES IN REPRODUCTIVE TOXICOLOGY

  • Vandevoort, Catherine A, (PI)
  • Xu, Xiping (PI)
  • Enan, Essam (PI)
  • Stewart, Dennis (PI)
  • Hendrickx, Andrew (PI)
  • Lasley, Bill (PI)
  • Hendrickx, Andrew G, (PI)

Project: Research project

Project Details

Description

Although the utility of biomarkers in reproductive toxicology is now
recognized and biomarkers are being applied by epidemiologists for
surveillance of environmental hazards to women's reproductive health,
there is still a lack of understanding of those specific agents or
classes of agents which may affect female fertility and fetal
development. There is also a lack of information on the mechanisms of
female reproductive toxicity, even when potential hazards have been
identified. Some of the pressing current needs which will be addressed
in this Program Project include: 1) to establish relevant experimental
systems including whole animal models and in vitro cell and tissue
cultures, which can be applied to gain better information on which
environmental factors may cause female infertility, implantation failure
and abnormal fetal development in humans; 2) to identify biological
markers of altered function in the ovary, preimplantation embryo, fetus
and reproductive tract which may be predictive of reproductive impairment
resulting from exposure to an exogenous agent; 3) to utilize reproductive
biomarkers for study of environmental toxicants and for definition of
their mechanisms of action at the level of organ systems, and ultimately,
at the cell and molecular level; and 4) to apply the results of animal
studies to identify new biomarkers for human epidemiology, and to enable
interpretation of data with existing biomarkers of reproductive effects
in human populations. The overall goals of this Program Project will be to develop sensitive
new end points for detection of reproductive toxicity in appropriate
animal models, and to utilize the knowledge gained from these animal
experiments to gather new human data and to interpret existing data from
epidemiological studies of human populations. This approach may enable
us to determine the biological target(s) of toxicity following human
exposures, and thereby, to identify the source of toxicity when there is
a complex environment or multiple exposures. To accomplish these
objectives we have assembled a team of 16 investigators representing the
primary disciplines which are the focus of this research (reproductive
toxicology, epidemiology, reproductive biology, reproductive medicine)
as well as related areas (endocrinology, developmental biology, cell
biology, molecular biology) which will be critical for support of these
studies.
StatusFinished
Effective start/end date8/1/931/31/06

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Environmental Science(all)
  • Medicine(all)

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