IN VIVO PILOT STUDY OF DEFENSINS

Project: Research project

Project Details

Description

Defensins are small cysteine rich antimicrobial peptides isolated from
macrophages and neutrophils. We have shown them to be very effective, in
vitro, against a broad spectrum of ocular pathogens isolated from clinical
cases of severe ulcerative keratitis. Additionally, we have shown
defensins to represent unique growth factors that markedly stimulate the
growth of corneal epithelial cells. This proposal is a pilot project to
test the use of these natural peptides as innovative topical therapeutic
agents in an animal model. Specifically, their effectiveness as topical
antimicrobial agents will be determined using a rabbit model of pseudomonas
and staphylococcus keratitis. In addition, their ability to facilitate
corneal epithelial wound healing will be evaluated in a rabbit model.
StatusFinished
Effective start/end date4/1/903/31/91

Funding

  • National Institutes of Health

ASJC

  • Medicine(all)

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