Human Functional Brain Anatomy

  • Mangun, George R (PI)
  • Labar, Kevin (PI)
  • Huettel, Scott (PI)
  • Song, Allen (PI)
  • Belger, Aysenil (PI)
  • Purves, Dale (PI)
  • Voyvodic, James (PI)
  • McCarthy, Gregory (PI)
  • Woldorff, Marty G. (PI)

Project: Research project

Project Details


DESCRIPTION (provided by applicant)
This Program Project will investigate the functional neuroanatomy of the human
brain using high-field functional magnetic resonance imaging (functional MRI),
electrophysiology, and behavior. The four scientific projects are strongly
linked by their focus on the relationship between brain and behavior. The
projects are organized into a logical progression from sensory processing
through response selection. Project 1 considers the relationship between
performance in elemental visual psychophysical tasks and the quantitative
structural anatomy of primary visual cortex (Vl). This project is technically
challenging and depends upon high-resolution fMRI-based retinotopic mapping to
discriminate V1 from other visual areas. Project 2 also focuses upon early
visual processing, however its emphasis is upon changes in processing as a
function of directed attention. Project 3 builds directly upon Project 2 by
investigating the domain specificity (space or feature) of attended visual
attributes that must be maintained in a transient memory store for later
processing. Project 3 also investigates the role of response processing and
sequential expectancies in prefrontal cortex. Project 4 will investigate the
manner in attention is attracted automatically or reflexively by novel and/or
distracting stimuli. The scientific projects are supported by three Cores. Core
A is administrative. Core B will develop methods in high-field functional MRI
designed to improve the functional resolution of brain imaging. This core will
develop and implement methods to improve the specificity of the MR signal to
brain parenchyma, to recover signal lost to large scale susceptibility
artifacts in ventral frontal and medial temporal regions, and to improve the
spatial and temporal resolution of BOLD contrast. Core C will develop and
implement methods for experimental control, physiological monitoring, and
analysis of structural and functional image data.
Effective start/end date4/1/018/31/12


  • National Institutes of Health


  • Medicine(all)
  • Neuroscience(all)


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