• Denison, Michael S (PI)
  • Upham, Brad L. (PI)
  • Hashsham, Syed A. (PI)
  • Goodman, Jay (PI)
  • Wallace, Roger (PI)
  • Chou, Karen (PI)
  • Pinnavaia, Thomas (PI)
  • Vogel, Timothy (PI)
  • Loch-Caruso, Rita Karen (PI)
  • Pinnavavia, Thomas (PI)
  • Fischer, Lawrence (PI)
  • Clemens, Lynwood (PI)
  • Conolly, Rory (PI)
  • Thomas, Russell (PI)
  • Zylstra, Gerben (PI)
  • Zacharewski, Timothy (PI)
  • Lapres, John (PI)
  • Ganey, Patricia (PI)
  • Voice, Thomas (PI)
  • Dukelow, W. Richard (PI)
  • Roth, Robert (PI)
  • Giesy, John (PI)
  • Olsen, R. (PI)
  • Harris, Craig (PI)
  • Madhukar, Burra (PI)
  • Abriola, Linda (PI)
  • Weber, Walter (PI)
  • Kamrin, Michael (PI)
  • Criddle, Craig (PI)
  • Trosko, James (PI)
  • Tiedje, James (PI)
  • Boyd, Stephen (PI)
  • Kaminski, Norbert (PI)

Project: Research project

Project Details


This application requests funds for support of biomedical and
ecoengineering research directed toward a better understanding of the
potential human health hazards arising from contamination of groundwater
with volatile organic compounds (VOCs) and for remediation of this
situation. A group of twenty-one scientists from Michigan State
University and the University of Michigan propose to conduct
collaborative research on ten different projects connected with VOC
contamination of groundwater caused by leaking waste storage sites.
Research connected with remediation of contamination will include studies
of the ability of microorganisms to degrade VOCs and the engineering-
based application of biodegradation process used alone or in connection
with adsorptive processes. Other studies will involve measurement of the
retention properties of clays and modified clays, and the abilities of
these materials to catalyze chemical degradation of VOCs. The transport
of volatile contaminants in soils and groundwater will be studied
experimentally and refined mathematical models describing this movement
will be developed for use in predicting time courses of contamination and
clean-up. Biomedical scientists will study the effects of VOCs on membrane-
connected functions associated with important biological processes.
Included will be studies of VOC effects on biomembrane structure,
activated neutrophil involvement in toxicity, gamete function and
embryonic growth, cell-cell communication, in addition to VOC-induced
changes in oncogene expression and possible roles in cancer promotion.
The results of this research will be used to help clarify the health
hazards of various VOCs and to direct the remediation research to
encompass VOCs that may cause the greatest health-related concerns. This
research effort will be accompanied by a training component designed to
give physical/chemical oriented graduate students sufficient
toxicological knowledge to facilitate their careers in research directed
toward remediation of environmental contamination by hazardous chemicals.
Effective start/end date12/7/883/31/18


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Environmental Science(all)
  • Medicine(all)


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.