Project: Research project

Project Details


The primary objective of the proposed investigation is to determine
the role of familial aggregation of cancer and/or congenital
malformations in the etiology of childhood brain tumors. The
investigators will also determine whether such familial aggregation
predisposes to (or interacts with) childhood brain tumors when the
child also has environmental exposures, such as parental
occupational exposures and prenatal exposure to maternal illnesses
drugs or smoking. The investigators propose to analyze data that were previously
collected with funding from the American Cancer Society and the
National Institute for Occupational Safety and Health. The cases
were identified from eight of the population-based Surveillance,
Epidemiology and End Results tumor registries in the United States
and consist of 361 children under 17 years of age with
histologically confirmed brain tumors. Three controls per case
were identified by random-digit-dialing, matching to cases on age,
sex, maternal racial/ethnic group and telephone prefix. Parents
of cases and controls were interviewed in-person in their homes
regarding personal and family medical history (including cancer and
congenital malformations), parental occupation, prenatal exposures
and other risk factors for brain tumors in children. In the present analysis, odds ratios will be used to estimate the
relative risk for familial aggregation as well as for occupational
and other exposures stratified by family history of cancer or
congenital malformations. A number of analyses and manuscripts
have resulted from the original study, most of which involve the
relationship of parental occupational exposures to the risk of
brain tumors in children. Funding is now requested to conduct
additional analyses on familial aggregation of cancer and
congenital malformations, the interaction of familial aggregation
with parental occupational exposures and the role of other risk
factors (particularly maternal prenatal illnesses an medications)
in the risk of brain tumors in children.
Effective start/end date7/1/8912/31/92


  • National Institutes of Health


  • Medicine(all)


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