Engineered Nanomaterials: Linking Physical and Chemical Properties to Biology

Project: Research project

Project Details

Description

The goal of this program is to systematically explore the influence of physicochemical properties of size,
composition, surface lability as well as charge, density, and activity of engineered nanomaterials (ENMs).
The goal of this project is to define the effect of these physical/chemical properties on how ENMs interact
with the intact organism, including specific target organs and specific cell types within the target organs. We
will focus one ofthe major classes of ENMs, the high aspect ratio nanomaterials (HARNMs), including single
wall carbon nanotubes (SWNTs) and nanowires (NWs) of various lengths. The importance of size (diameter
and length) and coatings (silica as one example) to affect toxicity, retention and translocation will be
assessed. HARNM with differing physical/chemical property described above will be employed in a series of
systematic examinations of absorption and distribution following inhalation/ingestion experiments. Primary
and secondary target organ responses will be monitored, and the influence of HARNM exposure In a model
of allergy will be assessed. The overall hypothesis Is that differences in composition, size, diameter and
surface coating of HARNMs will modulate the in vivo uptake, distribution and biologic effects of HARNMs in a
rat model. This hypothesis will be addressed in four specific aims that will determine the effect of HARNM
on 1) deposition, retention and distribution to various organs;2) respiratory system cytotoxicity, inflammation
and airway remodeling;3) oxidative stress in the respiratory system;and 4) exacerbation of ainway
hyperresposiveness in a sensitive model. We will address these aims using a transdisciplinary approach
that combines inhalation toxicology, chemistry, histopathology, high resolution imaging and novel
methodologies developed at UC Davis that uniquely position us to successfully address the biological effects
of these materials. The long term goal is to identify features of these materials that reduce their toxicity and
biological effects.
RELEVANCE (See instnjctions);
To develop and evaluate techniques and approaches to assess the potential disease burden associated with
exposures to ENMs. The goal of Project 2 is to define exposure effects of high aspect ratio nanomaterials
(single walled carbon nanotubes and nanowires) in an in vivo inhalation model that includes airways
hyperresonsiveness.
StatusFinished
Effective start/end date9/27/104/30/16

Funding

  • National Institutes of Health: $478,381.00
  • National Institutes of Health: $497,386.00
  • National Institutes of Health: $521,181.00
  • National Institutes of Health: $483,061.00
  • National Institutes of Health: $482,875.00

ASJC

  • Environmental Science(all)
  • Medicine(all)

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