CRANIOFACIAL BONE REGENERATION IN PRIMATES BY BMPS

Project: Research project

Project Details

Description

DESCRIPTION The recently
isolated and characterized bone morphogenetic proteins (BMPs) induce
endochondral bone differentiation in vivo. Molecular cloning and
expression of human recombinant BMPs may provide the potential for
controlled initiation of bone regeneration and repair in man. While
substantial progress is being made in the elucidation of the molecular
and cellular mechanisms involved in BMP- induced bone differentiation,
the morphogenetic potential of BMPs is predominantly based on work in
rodents.The long-term objective of the proposed research is to study the
efficacy and safety of native and recombinant BMPs delivered by suitable
carriers in a nonhuman primate model. This work has relevance to the
repair and regeneration of bone in congenital and acquired craniofacial
anomalies in man. The applicant proposes to investigate the efficacy and
safety of native and recombinant BMPs using nonhealing calvarial defects
of adult male baboons (Papio ursinus). The specific aims are first, to
determine the optimal dose of recombinant human BMP that will elicit a
repair comparable to native BMPs; Second, to determine if the rate and
extent of bone formation can be accelerated by increasing doses of
recombinant BMP; third, to determine the fate and long term remodeling
of the newly induced bone by recombinant BMP. Histology and
histomorphometry will be used to quantitate the extent of bone
regeneration induced by different doses of human recombinant BMP (HrBMP)
at different observation periods, and delivered either by collagenous
matrix or porous hydroxyapatite substrata.
StatusFinished
Effective start/end date9/30/939/29/96

Funding

  • National Institutes of Health
  • National Institutes of Health: $72,649.00
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Dentistry(all)

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