DESCRIPTION (provided by applicant): Controllers are defined as individuals who control plasma HIV RNA levels to 2,000 copies or below for many years in the absence of highly active antiretroviral therapy (HAART). Our previous work revealed that many Controllers have unusually strong, polyfunctional HIV-specific CD8+ T-cell responses at tissue sites of viral replication, such as the gastrointestinal mucosa. Despite their ability to contain viral replication, these individuals form a heterogeneous group;at least some of whom ultimately progress to CD4 decline and AIDS-defining illnesses. In preliminary studies, HIV Controllers had significantly higher CSF viral loads than HIV+ patients on HAART with suppressed viremia (P10,000 vRNA copies/mL;HAART-suppressed individuals with VL
|Effective start/end date||9/25/09 → 8/31/11|
- National Institutes of Health: $196,418.00
- National Institutes of Health: $225,489.00
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