CHOLECYSTOKININ AND ENTEROGASTRIC ACID INHIBITION

Project: Research project

Description

The goal of this project is to determine the sensory and effector
mechanisms mediating enterogastric reflex inhibition of gastric acid
secretion by intestinal fat. Because cholecystokinin is emerging as a
physiological regulator of acid secretion, its role in enterogastric acid
inhibition specifically will be investigated. Indeed, this study is based
on recent evidence indicating that CCK may stimulate a vago-vagal reflex
inhibitory pathway from the intestine to the stomach. It is well known that the presence of nutrients in the intestine after a
meal stimulates pancreatic protein and biliary secretion during the post-
prandial period. In addition, dietary fats are an especially potent
inhibitor of gastric emptying and acid secretion. There is good evidence
that CCK is mediating at least the acid inhibitory response, but the
transmission process and effector mechanism for the alteration of gastric
acid secretion are not yet known. It is still not clear if CCK is acting
principally as a hormonal inhibitor of acid secretion, or whether it can
exert its effect on the stomach by neurally-mediated, paracrine release of
gastric somatostatin. Therefore, this project will use in vivo regulatory physiology,
electrophysiology, and immunohistochemistry to thoroughly investigate the
enterogastric inhibitory pathways. Because CCK is a prime candidate to
initiate this effect, these studies also will address the mechanisms of
action of CCK as an enterogastrone.
StatusFinished
Effective start/end date9/25/933/31/05

Funding

  • National Institutes of Health
  • National Institutes of Health: $219,592.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $83,660.00
  • National Institutes of Health: $82,127.00
  • National Institutes of Health: $220,894.00
  • National Institutes of Health: $220,708.00
  • National Institutes of Health

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Cholecystokinin
Stomach
Acids
Intestines
Gastric Acid
Electrophysiology
Gastric Emptying
Dietary Fats
Reflex
Meals
Somatostatin
Immunohistochemistry
Fats
Food
Proteins
Inhibition (Psychology)
Intestinal Secretions
enterogastrone

ASJC

  • Medicine(all)