• Farnham, Peggy (PI)
  • Laishes, Brian (PI)
  • Burgess, Richard (PI)
  • Drinkwater, Norman R. (PI)
  • Fahl, William (PI)
  • Panganiban, Antonito (PI)
  • Hanson, June (PI)
  • Riegel, Ilse (PI)
  • Fechner, D.O.N. (PI)
  • Martinson, Randy (PI)
  • Niece, Ronald (PI)
  • Pitot, Henry (PI)
  • Pitot, Henry (PI)
  • Pitot, Henry (PI)
  • Risser, Rex (PI)
  • Ross, Jeffrey (PI)
  • Miller, Elizabeth (PI)
  • Pifot, Henry (PI)
  • Lambert, Paul (PI)
  • Kasper, Charles (PI)
  • Sugden, William M. (PI)

Project: Research project

Project Details


The research of the McArdle Laboratory for Cancer Research is divided into
three broad categories: Biochemical Studies in Chemical Carcinogenesis,
Molecular Biology and Genetics of Tumor Viruses, and The Cell Cycle and
Differentiation in Tumor Biology. The chemical carcinogenesis program
encompasses a broad fundamental a approach to the chemistry, biochemistry,
and biology of mutation, tumor initiation, and tumor promotion due to
chemicals. These projects include studies on the genetic control of
initiation and promotion, the biochemical regulation of enzyme activities,
the metabolic activation of carcinogens, the characterization of cellular
receptors for tumor promoters, and the analysis of preneoplastic lesions.
The studies in tumor virology encompass the molecular biology and genetics
of avian and murine RNA tumor viruses and of three primate DNA tumor
viruses, simian virus 40, papillomaviruses, and Epstein-Barr virus. This
tumor virology program approaches problems of the identification of viral
genes responsible for cancer, their mechanisms of transformation and
control of tissue specificity, the mechanisms of integration or maintenance
of viral genomes, the control of expression of viral genes, and the con-
struction and properties of vectors based on tumor viruses. The tumor
biology program is a multidisciplinary approach to the elucidation of
regulatory mechanisms that influence the growth, replication, and
differentiation of normal and cancer cells. For instance, this program
examines factors affecting the transcription of specific genes and the role
of RNA structure in its intracellular-localization, stability, and expres-
sion. The importance of cell membranes for cell replication control and
immune recognition, as well as for the regulation of cell differentiation,
are being investigated in a range of eukaryotic systems. Integral to the objectives and aims of the McArdle Laboratory is research
training at the pre- and postdoctoral levels in the general area of the
cell and molecular biology of neoplasia and carcinogenesis. Approximately
100 individuals are presently receiving such training in the McArdle
Laboratory, and more than 700 have received research training in these
areas in the McArdle Laboratory in the past.
Effective start/end date9/1/783/31/01


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)


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