BURN INJURY HERPESVIRUSES AND IMMUNITY

Project: Research project

Description

Since herpesvirus infections have been recognized in a significant number
of pediatric patients with thermal injury further studies in this patient
population are warranted. These studies are designed to definitively
investigate the frequency and clinical significance of herpes simplex virus
and cytomegalovirus infection in burned children and to investigate the
role of these agents in burned adults. Through the use of measurements of
specific lymphocyte transformation responses to viral antigens and through
the development of techniques to measure the production of interferon gamma
in response to viral antigens, cellular immune deficiencies which may
produce increased susceptibility to these agents will be investigated.
With increased understanding of the natural history and importance of these
infections in these patients strategies for interruption of transmission or
decreasing clinical impact will be designed. Studies in a murine model of thermal injury are designed to investigate
abnormalities in interferon production which may predispose to infection,
which remains the leading cause of mortality in burned individuals. The
development of a murine model of cytomegalovirus infection will permit
investigations of interferon responses in infected mice which will parallel
studies in humans. Experiments combining mouse cytomegalovirus infection
with thermal injury should provide increased understanding of the
immunologic consequences caused by the interaction between this infection
and trauma. Investigations into the infectious complications of thermal
injury, their clinical importance and the immmunologic alterations
associated either with the infectious agent or the insult itself should
increase the knowledge concerning this devastating and common event in
humans.
StatusFinished
Effective start/end date12/1/8411/30/87

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Herpesviridae
Immunity
Interferons
Muromegalovirus
Viral Antigens
Hot Temperature
Wounds and Injuries
Cytomegalovirus Infections
Herpesviridae Infections
Herpes Simplex
Lymphocyte Activation
Natural History
Pediatrics
Mortality
Infection

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)