Project: Research project

Project Details


The long-term objectives are (1) to evaluate the safety of diagnostic
ultrasound and pulsed Doppler in an in vivo system similar to the human,
and (2) to observe if changes in animals exposed prenatally to ultrasound
(scan mode) are the same for pulsed Doppler. Although considered
noninvasive, the safety of prenatal ultrasound exposure still remains
uncertain. The current trend to recommend its use as a screening device in
all pregnancies further intensifies the importance of these investigations.
The proposed studies incorporate a nonhuman primate (Macaca fascicularis)
as a model for the human and a commercial ultrasound unit (ATL, MK 600).
Periodic measurements of acoustic output including total power, ISPTA,
ISPPA, and peak rarefactional and compressional pressure will be included
in order to adequately evaluate exposure. In addition, temporal waveforms
at each location will be recorded and stored throughout the field. Studies
designed to evaluate the teratogenic potential of prenatal exposure in
laboratory rodents have indicated an increase in the rate of malformations
although long insonation times were incorporated. A significant rise in
intrauterine temperature (i.e. >2.5degreesC) may be expected with lengthy
exposure although an increase of this magnitude would not be expected in a
clinical setting. It is proposed that a moderate increase in intrauterine
temperature (
Effective start/end date6/1/905/31/95


  • National Institutes of Health


  • Medicine(all)


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